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You can disable Microsoft Defender real-time protection as follows:

Set-MpPreference -DisableRealtimeMonitoring $true

Disable cloud-based protection:

Set-MpPreference -MAPSReporting 0​

This will suspend antivirus protection in Windows until the next restart.

1. Run the gpedit.msc console;
2. Go to the following GPO section: Computer Configuration > Administrative Templates > Windows Components > Microsoft Defender Antivirus;
3. Find the parameter named Turn off Windows Defender Antivirus on the right pane;
4. Change its value to Enabled;

https://theitbros.com/managing-windows-defender-using-powershell/