How to Suspend the Microsoft Defender Antivirus Protection?

You can disable Microsoft Defender real-time protection as follows: 

Set-MpPreference -DisableRealtimeMonitoring $true

Disable cloud-based protection: 

Set-MpPreference -MAPSReporting 0​

This will suspend antivirus protection in Windows until the next restart.

Permanantly disable the real time protection

To uninstall Windows Defender on Windows Server 2022, you can use the following methods:

PowerShell 

Uninstall-WindowsFeature -Name Windows-Defender

reboot required

Remove Roles and Features wizard Use the wizard to install or uninstall roles, role services, or features. In the Features step, clear the Windows Defender Features option

Group Policy In the Local Group Policy Editor, navigate to:

  1. Administrative Template
  2. Windows Component
  3. Endpoint Protection
  4. Disable Endpoint Protection
  5. Select Enabled and then OK

https://theitbros.com/managing-windows-defender-using-powershell/